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Triazavirin - Wikipedia TriazavirinFrom Wikipedia, the free encyclopedia
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CAS Number
PubChem CID
CompTox Dashboard ( EPA )
ECHA InfoCard 100.217.074 Edit this at Wikidata
Chemical and physical data
Formula C 5 H 4 N 6 O 3 S
Molar mass 228.189 g·mol −1
3D model ( JSmol )

Triazavirin ( TZV ) is a broad-spectrum antiviral drug developed in Russia through a joint effort of Ural Federal University , Russian Academy of Sciences , Ural Center for Biopharma Technologies and Medsintez Pharmaceutical. It has a novel triazolotriazine core, which represents a new structural class of non-nucleoside antiviral drugs. It was originally developed as a potential treatment for pandemic influenza strains such as H5N1 , and most of the testing that has been done has focused on its anti-influenza activity. However triazavirin has also been found to have antiviral activity against a number of other viruses including Tick-borne encephalitis virus , and Forest-Spring Encephalitis virus, and is also being investigated for potential application against Lassa fever and Ebola virus disease . In February 2020, testing of triazavirin was started against SARS-CoV-2 .

See also[ edit ] BCX4430 Brincidofovir Favipiravir Umifenovir References[ edit ]Rusinov VL, Sapozhnikova IM, Ulomskii EN, Medvedeva NR, Egorov VV, Kiselev OI, et al. (2015). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds. 51 (3): 275–280. doi : 10.1007/s10593-015-1695-4 . Loginova SI, Borisevich SV, Maksimov VA, Bondarev VP, Kotovskaia SK, Rusinov VL, et al. (2007). "[Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture]". Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic] (in Russian). 52 (11–12): 18–20. PMID   19275052 .Karpenko I, Deev S, Kiselev O, Charushin V, Rusinov V, Ulomsky E, et al. (May 2010). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication" . Antimicrobial Agents and Chemotherapy. 54 (5): 2017–22. doi : 10.1128/AAC.01186-09 . PMC   2863629 . PMID   20194696 .Kiselev OI, Deeva EG, Mel'nikova TI, Kozeletskaia KN, Kiselev AS, Rusinov VL, et al. (2012). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii (in Russian). 57 (6): 9–12. PMID   23477247 .Loginova SI, Borisevich SV, Rusinov VL, Ulomskiĭ UN, Charushin VN, Chupakhin ON (2014). "[Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture]". Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic] (in Russian). 59 (1–2): 3–5. PMID   25051708 .Loginova SY, Borisevich SV, Rusinov VL, Ulomsky EN, Charushin VN, Chupakhin ON, Sorokin PV. Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice (Russian). Antibiot Khimioter. 2015;60(7-8):11-3. PMID   26863736 "Target: Ebola" . Pravda. Retrieved 18 January 2015. "Yekaterinburg pharmacies to sell domestic antiviral drug" . Retrieved 18 January 2015. "Ebola crisis: Vaccine 'too late' for outbreak. BBC News, 17 October 2014" . BBC News. Kukil Bora. Russia Will Begin Testing Triazavirin, Used For Lassa Fever, And Other Drugs On Ebola: Health Ministry. International Business Times, 12 November 2014 Darya Kezina. New antiviral drug from Urals will help fight Ebola and other viruses. Russia Beyond the Headlines, 12 November 2014 Jamshaid U. China Testing Russia's Triazavirin As Coronavirus Treatment - Russian Health Ministry. Urdupoint, 4 Feb 2020 "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak ' " . Retrieved 11 February 2020. "China Tests Russian Antiviral Drug Which Might Treat Coronavirus As Moscow Warns Of Possible 'Mass Outbreak ' " . Retrieved 11 February 2020. Retrieved from " https://en.wikipedia.org/w/index.php?title=Triazavirin&oldid=941774170 " Categories : Antivirals Experimental drugs Lactams Thioethers Nitrogen heterocycles Heterocyclic compounds (2 rings) Russian drugs Russian inventions Triazoles Antiinfective agent stubs Hidden categories: CS1 Russian-language sources (ru) ECHA InfoCard ID from Wikidata Articles without EBI source Chemical pages without DrugBank identifier Articles without KEGG source Articles without UNII source Drugs missing an ATC code Articles containing unverified chemical infoboxes All stub articles Navigation menuPersonal toolsNot logged in Talk Contributions Create account Log in Namespaces Article Talk VariantsViews Read Edit View history MoreSearch
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