Triazavirin - Wikipedia
TriazavirinFrom Wikipedia, the free encyclopedia
) is a broad-spectrum
through a joint effort of
Ural Federal University
Russian Academy of Sciences
, Ural Center for Biopharma Technologies and Medsintez Pharmaceutical. It has a novel triazolotriazine core, which represents a new structural class of non-nucleoside antiviral drugs.
It was originally developed as a potential treatment for pandemic
strains such as
, and most of the testing that has been done has focused on its anti-influenza activity.
However triazavirin has also been found to have antiviral activity against a number of other viruses including
Tick-borne encephalitis virus
and Forest-Spring Encephalitis virus,
and is also being investigated for potential application against
Ebola virus disease
In February 2020, testing of triazavirin was started against
]Rusinov VL, Sapozhnikova IM, Ulomskii EN, Medvedeva NR, Egorov VV, Kiselev OI, et al. (2015). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds. 51 (3): 275–280.
Loginova SI, Borisevich SV, Maksimov VA, Bondarev VP, Kotovskaia SK, Rusinov VL, et al. (2007). "[Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture]". Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic] (in Russian). 52 (11–12): 18–20.
.Karpenko I, Deev S, Kiselev O, Charushin V, Rusinov V, Ulomsky E, et al. (May 2010).
"Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication"
. Antimicrobial Agents and Chemotherapy. 54 (5): 2017–22.
.Kiselev OI, Deeva EG, Mel'nikova TI, Kozeletskaia KN, Kiselev AS, Rusinov VL, et al. (2012). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii (in Russian). 57 (6): 9–12.
.Loginova SI, Borisevich SV, Rusinov VL, Ulomskiĭ UN, Charushin VN, Chupakhin ON (2014). "[Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture]". Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic] (in Russian). 59 (1–2): 3–5.
.Loginova SY, Borisevich SV, Rusinov VL, Ulomsky EN, Charushin VN, Chupakhin ON, Sorokin PV. Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice (Russian). Antibiot Khimioter. 2015;60(7-8):11-3.
. Pravda. Retrieved 18 January 2015.
"Yekaterinburg pharmacies to sell domestic antiviral drug"
. Retrieved 18 January 2015.
"Ebola crisis: Vaccine 'too late' for outbreak. BBC News, 17 October 2014"
. BBC News.
Kukil Bora. Russia Will Begin Testing Triazavirin, Used For Lassa Fever, And Other Drugs On Ebola: Health Ministry. International Business Times, 12 November 2014
Darya Kezina. New antiviral drug from Urals will help fight Ebola and other viruses. Russia Beyond the Headlines, 12 November 2014
Jamshaid U. China Testing Russia's Triazavirin As Coronavirus Treatment - Russian Health Ministry. Urdupoint, 4 Feb 2020
"China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak
. Retrieved 11 February 2020.
"China Tests Russian Antiviral Drug Which Might Treat Coronavirus As Moscow Warns Of Possible 'Mass Outbreak
. Retrieved 11 February 2020.
Retrieved from "
Heterocyclic compounds (2 rings)
Antiinfective agent stubs
CS1 Russian-language sources (ru)
ECHA InfoCard ID from Wikidata
Articles without EBI source
Chemical pages without DrugBank identifier
Articles without KEGG source
Articles without UNII source
Drugs missing an ATC code
Articles containing unverified chemical infoboxes
All stub articles
Navigation menuPersonal toolsNot logged in
Donate to Wikipedia
What links here
Cite this page
Create a book
Download as PDF
This page was last edited on 20 February 2020, at 16:13 (UTC).Text is available under the
Creative Commons Attribution-ShareAlike License
additional terms may apply. By using this site, you agree to the
. Wikipedia® is a registered trademark of the
Wikimedia Foundation, Inc.
, a non-profit organization.